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Epidemiology of multiple myeloma in Taiwan: Wed Nov 28 Multiple Myeloma MM is a cancer of plasma cells resulting from the abnormal proliferation of malignant plasma cells within the bone marrow BM microenvironment. This paper is an update of Multiple myeloma in Antigen-selected, post-germinal center, terminally differentiated plasma cell Anderson and Carrasco The most common presenting symptoms of MM are fatigue and bone or back pain.
Both criteria must be met: Osteolytic bone lesions a-d X-rays showing characteristic osteolytic bone lesions typical sites such as the a skull, b tibia, c femur, and d pelvis. NCCN guidelines version 3. Not recommended for use as an indicator of response; stability of disease is best described by providing the time-to-progression estimates. Not meeting criteria for complete response, very good partial response, partial response, minimal response, or progressive disease. Any one or more of the following criteria: Clinical relapse requires one or more of the following criteria: Subsequent evaluations can be used to further specify the duration of negativity eg, MRD-negative at 5 years.
Absence of clonal plasma cells by NGS on bone marrow aspirate in which presence of a clone is defined as less than two identical sequencing reads obtained after DNA sequencing of bone marrow aspirates using the LymphoSIGHT platform or validated equivalent method with a minimum sensitivity of 1 in 10 5 nucleated cells or higher. Varies greatly depending on: Trisomy ies without IgH abnormality. Highly responsive to revlimid-based therapy. High levels of FLC and high rate of kidney damage.
Other cytogenetic abnormalities in absence of 1 IgH translocations, 2 trisomy ies , or 3 monosomy Genes involved and Proteins. Involved in t 11;14 q13;q32 Incidence: Involved in t 6;14 p21;q32 Incidence: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog avian. Involved in t 14;16 q32;q23 Incidence: IRF4 interferon regulatory factor 4. Involved in t 6;14 p25;q32 Incidence: MYC v-myc myelocytomatosis viral oncogene homolog avian. MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B.
Involved in t 14;20 q32;q11 Incidence: IL6R interleukin 6 receptor. Interpretation of cytogenetic results in multiple myeloma for clinical practice. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.
Translocations implicated Data extracted from papers in the Atlas.